New Article

Baysal BE, Lawrence EC, Ferrell RE.
Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA.
BMC Biol. 2007 Mar 21;5:12. PMID: 17376234

New Complex II Polymorphism database:

Database address:
http://chromium.liacs.nl/lovd_sdh/
Publication:
Jean-Pierre Bayley, Peter Devilee1, and Peter EM Taschner.(2005) The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency
BMC Medical Genetics 2005, 6:39 doi:10.1186/1471-2350-6-39

Recent Article: Complex II in leukemia?

A Recurrent Stop-Codon Mutation in Succinate Dehydrogenase Subunit B Gene in Normal Peripheral Blood and Childhood T-Cell Acute Leukemia.
Bora E. Baysal, May 2007, PLoS ONE Online Journal

Wolinella succinogenes QFR has a cis-Asp!

(larger image) Wolinella succinogenes QFR flavoprotein has a cis-Asp! Model w atom labels is 2BS2, maps calculated with phases from it using SF's sf2bs2.cif. Other model is chicken complex II, superimposing the FAD domain. Green and red maps are positively and negatively contoured Fo-Fc maps- green on the chickenmodel shows where the atom should be, red on the Wolli atom shows it is misplaced. Apparently this cis-peptide occurs in all membrane-bound SDH/QFR enzymes solved to date. Soluble FCc FRD from Shewanella has a deletion here and no cis-peptide. The cis-peptide introduces a bulge which accomodates the extra residue. This is near the active site and an enigmatic conserved protein-bound metal ion (yellow crosses at bottom center).

Recent Article

Dicoumarol impairs mitochondrial electron transport and pyrimidine biosynthesis in human myeloid leukemia HL-60 cells. Biochem Pharmacol. 2007 Feb 1;73(3):427-39. Epub 2006 Oct 21. PMID: 17123468 (Dicoumarol stimulates ROS production, potentiated by Complex II Q-site inhibitors.)

Recent Article

Bacsi A, Woodberry M, Widger W, Papaconstantinou J, Mitra S, Peterson JW, Boldogh I. Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells. Mitochondrion. 2006 Oct;6(5):235-44.
PMID: 17011837

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