Thursday, July 26, 2007

New Q-site article

Szeto SS, Reinke SN, Sykes BD, Lemire BD. Ubiquinone-binding site mutations in the saccharomyces cerevisiae succinate dehydrogenase generate superoxide and lead to the accumulation of succinate.
J Biol Chem. 2007 Jul 18; PMID: 17636259

Firmer evidence for involvement of Complex II in Huntingtons

Benchoua A, Trioulier Y, Zala D, Gaillard MC, Lefort N, Dufour N, Saudou F, Elalouf JM, Hirsch E, Hantraye P, Déglon N, Brouillet E.
Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin.
Mol Biol Cell. 2006 Apr;17(4):1652-63.